However, the til tailya group did not show a significant reduction in lung pathology. In line with reduced viral load, histopathological analysis revealed a reduction in lung pathology in the Anu oil group as compared to the control infected group. Prophylactic intra-nasal instillation of these oil formulations exhibited reduced viral load in lungs and resulted in reduced body weight loss and lung-pneumonitis. Herein, we report the prophylactic application of two intranasal formulations provided by the National Medicinal Plant Board (NMPB), Anu oil and til tailya, in the hamster model of SARS-CoV-2 infection.
Thus, therapeutics aimed at inhibiting the entry of the virus or its internalization in the upper respiratory tract are of interest. Severe COVID-19 is characterized by pulmonary pathologies associated with respiratory failure. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection initiates with viral entry in the upper respiratory tract, leading to coronavirus disease 2019 (COVID-19).
3DG(I/C), Central Council for Ayurvedic Sciences, New Delhi, India.2Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India.
1Immuno-biology Laboratory, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India.Sastry 4, Shailendra Mani 2, Milan Surjit 2, Amit Awasthi 1* and Madhu Dikshit 5* Zaigham Abbas Rizvi 1, Manas Ranjan Tripathy 1, Nishant Sharma 2, Sandeep Goswami 1, N Srikanth 3, J.
0 kommentar(er)
